Interaction of Staphylococcus aureus toxin "superantigens" with human T cells

Proc Natl Acad Sci U S A. 1989 Nov;86(22):8941-5. doi: 10.1073/pnas.86.22.8941.

Abstract

A modification of the polymerase chain reaction has been used to establish the fact that a collection of Staphylococcus aureus toxins are "superantigens," each of which interacts with the T-cell alpha beta receptor of human T cells by means of a specific set of V beta elements.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antigens, Bacterial / immunology*
  • Antigens, Differentiation, T-Lymphocyte / genetics*
  • Antigens, Differentiation, T-Lymphocyte / immunology
  • Bacterial Toxins / immunology*
  • Base Sequence
  • CD3 Complex
  • Genes
  • Humans
  • Macromolecular Substances
  • Mice
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • RNA / genetics
  • Receptors, Antigen, T-Cell / genetics*
  • Receptors, Antigen, T-Cell / immunology
  • Species Specificity
  • T-Lymphocytes / immunology*

Substances

  • Antigens, Bacterial
  • Antigens, Differentiation, T-Lymphocyte
  • Bacterial Toxins
  • CD3 Complex
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell
  • RNA