Postoperative adverse effects after recent or remote lithium therapy

Samuel A Irefin; Abraham Sonny; Lisa Harinstein; Marc J Popovich

doi:10.1016/j.jclinane.2013.11.017

Postoperative adverse effects after recent or remote lithium therapy

J Clin Anesth. 2014 May;26(3):231-4. doi: 10.1016/j.jclinane.2013.11.017. Epub 2014 May 3.

Authors

Samuel A Irefin¹, Abraham Sonny², Lisa Harinstein³, Marc J Popovich²

Affiliations

¹ Department of General Anesthesiology, Cleveland Clinic, 9500 Euclid Ave./E31, Cleveland, OH 44195, USA. Electronic address: [email protected].
² Department of General Anesthesiology, Cleveland Clinic, 9500 Euclid Ave./E31, Cleveland, OH 44195, USA.
³ Department of Pharmacy, Cleveland Clinic, 9500 Euclid Ave./Hb105, Cleveland, OH 44195, USA.

PMID: 24793702
DOI: 10.1016/j.jclinane.2013.11.017

Abstract

Patients receiving preoperative lithium therapy for bipolar disorder may present unique challenges in the perioperative period and during critical illness. Two cases of critically ill patients who developed lithium-induced adverse reactions in the perioperative period due to the low therapeutic index are reported.

Keywords: Bipolar disorder; Drug reactions; Hypernatremia; Hypovolemia; Lithium; Nephrogenic diabetes insipidus.

Publication types

Case Reports

MeSH terms

Antimanic Agents / administration & dosage
Antimanic Agents / adverse effects*
Bipolar Disorder / drug therapy*
Critical Illness
Female
Humans
Lithium Compounds / administration & dosage
Lithium Compounds / adverse effects*
Middle Aged
Postoperative Period

Substances

Antimanic Agents
Lithium Compounds