Population-based disparities in survival among patients with core-binding factor acute myeloid leukemia: a SEER database analysis

Leuk Res. 2014 Jul;38(7):773-80. doi: 10.1016/j.leukres.2014.04.001. Epub 2014 Apr 12.

Abstract

We performed a retrospective population-based study using the SEER database to assess survival trends in CBF-AML between 2000 and 2010. Median OS increased from 16 months in 2000-2002 to 25 months in 2006-2008 (P=0.002). The 3-year OS rate for patients with inv(16) was 57.3%, but in t(8;21) was only 35.5%. Patients aged 75-84 had worse survival than patients aged 15-44 (HR 5.61, P=0.0002). Black race was associated with higher mortality (HR 1.50, P=0.03). Compared to clinical trial outcomes, CBF-AML survival is poorer in the general population, particularly among African Americans and the elderly, and in t(8;21) compared to inv(16) AML.

Keywords: Acute myeloid leukemia; Core binding factors; Health status disparities; Population surveillance; Survival.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Chromosomes, Human, Pair 21
  • Chromosomes, Human, Pair 8
  • Core Binding Factors / metabolism*
  • Databases, Factual
  • Humans
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / mortality*
  • Middle Aged
  • Retrospective Studies
  • SEER Program*
  • Translocation, Genetic

Substances

  • Core Binding Factors