Fetal sexual differentiation results from complex subsequent intracellular signaling and hormonal events that interact together in a definite timing. This process contributes to the setting of gonad determination, internal and external genitalia resulting in a female or male phenotype. Here, we review our current knowledge of gonadal determination drawing on insights from knock-out and transgenic mouse models and analysis of patients with disorders of sex development (DSD).
Keywords: Différenciation sexuelle; Disorders of sex development; Détermination gonadique; Gonad determination; Human gene mutation; Pathologie humaine; Sex determination; Souris transgénique; Transgenic mouse models.
Copyright © 2014. Published by Elsevier Masson SAS.