Life threatening causes of syncope: channelopathies and cardiomyopathies

Auton Neurosci. 2014 Sep:184:53-9. doi: 10.1016/j.autneu.2014.04.003. Epub 2014 Apr 22.

Abstract

Syncope is common, has a high recurrence rate and carries a risk of morbidity and, dependent on the cause, mortality. Although the majority of patients with syncope have a benign prognosis, syncope as a result of cardiomyopathy or channelopathy carries a poor prognosis. In addition, the identification of these disorders allows for the institution of treatments, which are effective at reducing the risk of both syncope and mortality. It is for these reasons that the identification of a cardiomyopathy or channelopathy in patients with syncope is crucial. This review article will describe the characteristics of common cardiomyopathies and channelopathies and their investigation.

Keywords: Cardiomyopathy; Channelopathy; Syncope.

Publication types

  • Review

MeSH terms

  • Cardiomyopathies / complications*
  • Cardiomyopathies / diagnosis
  • Cardiomyopathies / genetics
  • Cardiomyopathies / physiopathology
  • Channelopathies / complications*
  • Channelopathies / diagnosis
  • Channelopathies / genetics
  • Channelopathies / physiopathology
  • Humans
  • Syncope / diagnosis
  • Syncope / etiology*
  • Syncope / genetics
  • Syncope / physiopathology