Abstract
To characterize the genetic properties of coxsackievirus A12 (CVA12) strains isolated from hand, foot and mouth disease (HFMD) patients in Qingdao during 2008-2011, the complete genome and VP1 coding region were sequenced and analyzed. Phylogenetic analysis showed that all strains from China clustered into three different branches, suggesting multiple lineages of CVA12 co-circulating in Asia. Sequence analysis indicated a monophyletic group only when the P1 region was examined, indicating possible recombination between CVA12 and other HEV-A serotypes. The emergence of CVA12 involved in an HFMD outbreak in China is a public-health issue.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Child, Preschool
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China / epidemiology
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Cluster Analysis
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Communicable Diseases, Emerging / epidemiology
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Communicable Diseases, Emerging / virology*
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Enterovirus / classification*
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Enterovirus / genetics*
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Enterovirus / isolation & purification
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Female
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Genotype
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Hand, Foot and Mouth Disease / epidemiology
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Hand, Foot and Mouth Disease / virology*
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Humans
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Infant
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Male
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Molecular Epidemiology
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Molecular Sequence Data
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Phylogeny
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RNA, Viral / genetics*
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Recombination, Genetic
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Sequence Analysis, DNA
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Viral Structural Proteins / genetics
Substances
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RNA, Viral
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Viral Structural Proteins
Associated data
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GENBANK/KF422142
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GENBANK/KF422143
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GENBANK/KF422144
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GENBANK/KF422145
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GENBANK/KF422146
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GENBANK/KF422147