1 From the Section of Anaesthesiology and Intensive Care, Department of Physiology and Pharmacology, The Karolinska Institute, and Paediatric Anaesthesia, Intensive Care & ECMO Services, ALB/Karolinska University Hospital-Solna, Stockholm, Sweden (PAL), and Department of Anesthesiology and Pain Medicine, University of Washington and Seattle Children's Hospital, Seattle, Washington, USA (ATB).