Anti-Candida activity of fluoxetine alone and combined with fluconazole: a synergistic action against fluconazole-resistant strains

Antimicrob Agents Chemother. 2014 Jul;58(7):4224-6. doi: 10.1128/AAC.02623-13. Epub 2014 May 5.

Abstract

The purpose of this work was to determine the antimicrobial activity of fluoxetine, alone and combined with fluconazole, against 29 Candida strains isolated from patients with vulvovaginal candidiasis. MIC and minimum lethal concentration values ranged from 9.8 to 625 μg/ml for all strains tested. The combination of fluconazole with fluoxetine resulted in synergistic activity against six Candida strains, with fractional inhibitory index (FIX) values between 0.15 and 0.31. An indifferent effect was found for the remaining strains, with FIX values between 0.63 and 1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Antifungal Agents / therapeutic use
  • Candida / classification
  • Candida / drug effects*
  • Candidiasis, Vulvovaginal / drug therapy
  • Candidiasis, Vulvovaginal / microbiology
  • Drug Resistance, Fungal
  • Drug Synergism
  • Drug Therapy, Combination
  • Female
  • Fluconazole / pharmacology*
  • Fluconazole / therapeutic use
  • Fluoxetine / pharmacology*
  • Fluoxetine / therapeutic use
  • Humans
  • Microbial Sensitivity Tests

Substances

  • Antifungal Agents
  • Fluoxetine
  • Fluconazole