Nano regulation of cisplatin chemotherapeutic behaviors by biomineralization controls

Small. 2014 Sep 24;10(18):3644-9. doi: 10.1002/smll.201303849. Epub 2014 May 5.

Abstract

Controllable biomineralization modification of cisplatin can alter the drug biodistribution with extended circulation time in blood. These changes increase passive tumor target and decrease non-specific accumulation significantly, which can improve chemotherapeutic effect with minimum side effects.

Keywords: biodistribution; biomineralization; cisplatin; nanoparticles; size effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Cell Line, Tumor
  • Cisplatin / administration & dosage*
  • Drug Carriers
  • Endocytosis
  • Humans
  • Lysosomes / metabolism
  • Male
  • Mice
  • Mice, Nude
  • Microscopy, Electron, Transmission
  • Nanomedicine / methods*
  • Nanoparticles / chemistry
  • Neoplasm Transplantation
  • Particle Size
  • Tissue Distribution

Substances

  • Antineoplastic Agents
  • Drug Carriers
  • Cisplatin