Abstract
In the present paper clinical phenotypes, pathogenetic relationships, and diagnostic algorithms as well as therapeutic concepts of/for systemic mast cell activation disease are reviewed. The reader should be able to recognize and diagnose a systemic mast cell activation disease, as well as to counsel a personalized drug therapy. In the case of chronic multisystem polymorbidity systemic mast cell activation disease should be considered as a differential diagnosis at an early stage. In most cases, specific, little invasive investigations allow diagnosing the disease and, hence, an appropriate therapy can be initiated.
© Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Case Reports
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English Abstract
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Review
MeSH terms
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Adult
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Algorithms
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Ascorbic Acid / administration & dosage
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Bone Marrow / pathology
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Child
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Combined Modality Therapy
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DNA Mutational Analysis
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Diagnosis, Differential
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Early Diagnosis
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Female
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Histamine H1 Antagonists / therapeutic use
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Humans
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Infant, Newborn
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Ketotifen / administration & dosage
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Mast Cells / pathology
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Mastocytosis, Systemic / classification
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Mastocytosis, Systemic / diagnosis*
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Mastocytosis, Systemic / drug therapy*
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Mastocytosis, Systemic / genetics
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Pregnancy
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Proto-Oncogene Proteins c-kit / genetics
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RNA, Messenger / genetics
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Ranitidine / administration & dosage
Substances
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Histamine H1 Antagonists
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RNA, Messenger
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Ranitidine
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Proto-Oncogene Proteins c-kit
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Ascorbic Acid
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Ketotifen