Modeling the effect of different vaccine effectiveness estimates on the number of vaccine-prevented influenza-associated hospitalizations in older adults

Alicia M Fry; Inkyu K Kim; Carrie Reed; Mark Thompson; Sandra S Chaves; Lyn Finelli; Joseph Bresee

doi:10.1093/cid/ciu328

Modeling the effect of different vaccine effectiveness estimates on the number of vaccine-prevented influenza-associated hospitalizations in older adults

Clin Infect Dis. 2014 Aug 1;59(3):406-9. doi: 10.1093/cid/ciu328. Epub 2014 May 6.

Authors

Alicia M Fry¹, Inkyu K Kim², Carrie Reed¹, Mark Thompson¹, Sandra S Chaves¹, Lyn Finelli¹, Joseph Bresee¹

Affiliations

¹ Influenza Division, Centers for Disease Control and Prevention.
² Influenza Division, Centers for Disease Control and Prevention Battelle Memorial Institute, Atlanta, Georgia.

PMID: 24803379
DOI: 10.1093/cid/ciu328

Abstract

We compared influenza vaccine-prevented hospitalizations in adults aged ≥65 years for a range of hypothetical effectiveness estimates. During 2012-2013, a vaccine with 10% effectiveness (66% coverage) would have averted approximately 13 000 hospitalizations, and a vaccine with 40% effectiveness would have averted approximately 60 000 hospitalizations. Annual vaccination is merited in this vulnerable population.

Keywords: hospitalization; influenza; older adults; vaccine effectiveness.

Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

MeSH terms

Aged
Aged, 80 and over
Hospitalization / statistics & numerical data
Humans
Influenza Vaccines / immunology*
Influenza, Human / immunology
Influenza, Human / prevention & control*
Models, Theoretical
Treatment Outcome
Vaccination*

Substances

Influenza Vaccines