The multivalent effect in glycosidase inhibition: a new, rapidly emerging topic in glycoscience

Chembiochem. 2014 Jun 16;15(9):1239-51. doi: 10.1002/cbic.201402026. Epub 2014 May 7.

Abstract

A bunch of keys, one lock: The multivalent effect in glycosidase inhibition is a new, rapidly emerging area with exciting potential and scope. This review presents a description of the different types of neoglycoclusters and their evaluation as glycosidase inhibitors. The first promising therapeutic applications are discussed, as well as the mechanisms underlying the observed inhibitory multivalent effect.

Keywords: click chemistry; glycosidases; iminosugars; inhibitors; multivalency.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Dose-Response Relationship, Drug
  • Drug Discovery
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology*
  • Glycoproteins / metabolism
  • Glycoside Hydrolases / antagonists & inhibitors*
  • Glycoside Hydrolases / metabolism
  • Glycosylation
  • Molecular Conformation
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Glycoproteins
  • Glycoside Hydrolases