Polymers fight HIV: potent (pro)drugs identified through parallel automated synthesis

Adv Healthc Mater. 2015 Jan 7;4(1):46-50. doi: 10.1002/adhm.201400148. Epub 2014 May 9.

Abstract

Macromolecular (pro)drugs interfere with the proliferation of HIV through both inhibition of viral cell entry and via intracellular delivery of antiviral drugs. Lead polymer conjugates exhibit longevity of action exceeding that of parent nucleoside analogue drug and are active in primary T cell over at least 72 h.

Keywords: HIV; drug delivery; polymers; prodrugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents* / chemical synthesis
  • Anti-HIV Agents* / chemistry
  • Anti-HIV Agents* / pharmacology
  • Biodegradable Plastics* / chemical synthesis
  • Biodegradable Plastics* / chemistry
  • Biodegradable Plastics* / pharmacology
  • Cell Line
  • Drug Carriers* / chemical synthesis
  • Drug Carriers* / chemistry
  • Drug Carriers* / pharmacology
  • HIV Infections / drug therapy*
  • HIV Infections / metabolism
  • HIV Infections / pathology
  • HIV-1 / metabolism*
  • Humans
  • Prodrugs* / chemical synthesis
  • Prodrugs* / chemistry
  • Prodrugs* / pharmacology
  • Zidovudine* / chemistry
  • Zidovudine* / pharmacology

Substances

  • Anti-HIV Agents
  • Biodegradable Plastics
  • Drug Carriers
  • Prodrugs
  • Zidovudine