Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture

Kenneth D Mandl; Isaac S Kohane; Douglas McFadden; Griffin M Weber; Marc Natter; Joshua Mandel; Sebastian Schneeweiss; Sarah Weiler; Jeffrey G Klann; Jonathan Bickel; William G Adams; Yaorong Ge; Xiaobo Zhou; James Perkins; Keith Marsolo; Elmer Bernstam; John Showalter; Alexander Quarshie; Elizabeth Ofili; George Hripcsak; Shawn N Murphy

doi:10.1136/amiajnl-2014-002727

Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS): architecture

J Am Med Inform Assoc. 2014 Jul-Aug;21(4):615-20. doi: 10.1136/amiajnl-2014-002727. Epub 2014 May 12.

Authors

Kenneth D Mandl¹, Isaac S Kohane¹, Douglas McFadden², Griffin M Weber³, Marc Natter⁴, Joshua Mandel⁴, Sebastian Schneeweiss⁵, Sarah Weiler⁶, Jeffrey G Klann⁷, Jonathan Bickel⁸, William G Adams⁹, Yaorong Ge¹⁰, Xiaobo Zhou¹¹, James Perkins¹², Keith Marsolo¹³, Elmer Bernstam¹⁴, John Showalter¹⁵, Alexander Quarshie¹⁶, Elizabeth Ofili¹⁷, George Hripcsak¹⁸, Shawn N Murphy¹⁹

Affiliations

¹ Children's Hospital Informatics Program at Harvard-MIT Health Sciences and Technology, Boston, Massachusetts, USA Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA Harvard Catalyst, Harvard Medical School, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
² Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA Harvard Catalyst, Harvard Medical School, Boston, Massachusetts, USA.
³ Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, USA Biomedical Research Informatics Core, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
⁴ Children's Hospital Informatics Program at Harvard-MIT Health Sciences and Technology, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
⁵ Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
⁶ Harvard Catalyst, Harvard Medical School, Boston, Massachusetts, USA.
⁷ Laboratory of Computer Science, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁸ Children's Hospital Informatics Program at Harvard-MIT Health Sciences and Technology, Boston, Massachusetts, USA Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA Information Services Department, Boston Children's Hospital, Boston, Massachusetts, USA.
⁹ Boston University School of Medicine/Boston Medical Center, Boston, Massachusetts, USA Boston University Clinical and Translational Sciences Institute, Boston, Massachusetts, USA.
¹⁰ College of Computing and Informatics, University of North Carolina at Charlotte, Charlotte, North Carolina, USA.
¹¹ Department of Radiology, Center for Bioinformatics & Systems Biology, Wake Forest University Health Science, Winston-Salem, North Carolina, USA.
¹² Clark Atlanta University, Atlanta, Georgia, USA Research Centers in Minority Institutions Translational Research Network, Data Coordinating Center, Jackson State University, Jackson, Mississippi, USA.
¹³ Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
¹⁴ Division of Biomedical Informatics, Biomedical Informatics and Department of Internal Medicine, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
¹⁵ University of Mississippi Medical Center, Jackson, Mississippi, USA.
¹⁶ Department of Internal Medicine, Community Health and Preventive Medicine and Clinical Research Center, Morehouse School of Medicine, Atlanta, Georgia, USA.
¹⁷ Department of Internal Medicine, Clinical Research Center, Morehouse School of Medicine, Atlanta, Georgia, USA.
¹⁸ Department of Biomedical Informatics, Columbia University, New York, New York, USA.
¹⁹ Laboratory of Computer Science, Massachusetts General Hospital, Boston, Massachusetts, USA Partners HealthCare Systems, Information Systems, Charlestown, Massachusetts, USA.

Abstract

We describe the architecture of the Patient Centered Outcomes Research Institute (PCORI) funded Scalable Collaborative Infrastructure for a Learning Healthcare System (SCILHS, http://www.SCILHS.org) clinical data research network, which leverages the $48 billion dollar federal investment in health information technology (IT) to enable a queryable semantic data model across 10 health systems covering more than 8 million patients, plugging universally into the point of care, generating evidence and discovery, and thereby enabling clinician and patient participation in research during the patient encounter. Central to the success of SCILHS is development of innovative 'apps' to improve PCOR research methods and capacitate point of care functions such as consent, enrollment, randomization, and outreach for patient-reported outcomes. SCILHS adapts and extends an existing national research network formed on an advanced IT infrastructure built with open source, free, modular components.

Keywords: Clinical Trials; Distributed Computing; Electronic Health Record; Learning Health System; Patient Engagement.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Computer Communication Networks*
Electronic Health Records / organization & administration*
Humans
Information Dissemination*
Organizations
Outcome Assessment, Health Care / organization & administration*
Patient-Centered Care*
United States

Abstract

Publication types

MeSH terms

Grants and funding