Black pigmented aortic valve and sinus of Valsalva caused by life-long minocycline therapy

Tomohiro Tsunekawa; Kent W Jones; John R Doty

doi:10.1093/icvts/ivu142

Black pigmented aortic valve and sinus of Valsalva caused by life-long minocycline therapy

Interact Cardiovasc Thorac Surg. 2014 Aug;19(2):339-40. doi: 10.1093/icvts/ivu142. Epub 2014 May 13.

Authors

Tomohiro Tsunekawa¹, Kent W Jones², John R Doty²

Affiliations

¹ Division of Cardiovascular and Thoracic Surgery, Intermountain Medical Center, Murray, UT, USA [email protected].
² Division of Cardiovascular and Thoracic Surgery, Intermountain Medical Center, Murray, UT, USA.

PMID: 24824497
DOI: 10.1093/icvts/ivu142

Abstract

Minocycline, a derivative of tetracycline, is a broad-spectrum antibiotic used in the treatment of various infections. Black discolouration of the skin, teeth, bones and the thyroid gland are sequelae of long-term minocycline therapy. We report an unusual case of minocycline-induced pigmentation of the aortic valve and sinuses of Valsalva.

Keywords: Aortic valve; Heart valve disease; Surgery.

Publication types

Case Reports

MeSH terms

Aged
Anti-Bacterial Agents / administration & dosage
Anti-Bacterial Agents / adverse effects*
Aortic Diseases / chemically induced*
Aortic Diseases / diagnosis
Aortic Valve / drug effects*
Aortic Valve / surgery
Aortic Valve Stenosis / diagnosis
Aortic Valve Stenosis / surgery
Biopsy
Drug Administration Schedule
Female
Heart Valve Diseases / chemically induced*
Heart Valve Diseases / diagnosis
Heart Valve Prosthesis Implantation
Hidradenitis / drug therapy
Hidradenitis / microbiology
Humans
Minocycline / administration & dosage
Minocycline / adverse effects*
Pigmentation / drug effects*
Pigmentation Disorders / chemically induced*
Pigmentation Disorders / diagnosis
Sinus of Valsalva / drug effects*

Substances

Anti-Bacterial Agents
Minocycline