Abstract
1. The effectiveness and tolerability of deprenyl as an adjunct in the therapy of parkinsonism was studied in a double-blind trial comprising 30 de novo patients. 2. Two thirds of the cases that could be evaluated showed a statistically significant improvement while on adjuvant deprenyl therapy. 3. The improvements are shown in the replugging test, a subtest of the Motor Performance Test, and on the Columbia University Rating Scale. 4. There is no statistically significant correlation between improvement of motor response and depression. 5. Deprenyl seems to be less effective in patients with low contents of HIAA and HVA in the cerebrospinal fluid.
MeSH terms
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Benserazide / therapeutic use*
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Depression / drug therapy*
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Double-Blind Method
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Drug Therapy, Combination
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Female
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Glycols / cerebrospinal fluid*
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Homovanillic Acid / cerebrospinal fluid*
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Humans
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Hydrazines / therapeutic use*
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Hydroxyindoleacetic Acid / cerebrospinal fluid*
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Levodopa / therapeutic use*
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Male
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Methoxyhydroxyphenylglycol / cerebrospinal fluid*
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Middle Aged
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Motor Activity / physiology*
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Parkinson Disease / cerebrospinal fluid
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Parkinson Disease / drug therapy*
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Parkinson Disease / physiopathology
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Parkinson Disease / psychology
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Phenethylamines / therapeutic use*
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Selegiline / therapeutic use*
Substances
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Glycols
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Hydrazines
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Phenethylamines
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Selegiline
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Levodopa
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Methoxyhydroxyphenylglycol
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Hydroxyindoleacetic Acid
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Benserazide
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Homovanillic Acid