Mn(II)-containing coordination nanoparticles as highly efficient T(1) contrast agents for magnetic resonance imaging

Gabriella Paul; Yoann Prado; Nada Dia; Eric Rivière; Sophie Laurent; Mathieu Roch; Luce Vander Elst; Robert N Muller; Lucie Sancey; Pascal Perriat; Olivier Tillement; Talal Mallah; Laure Catala

doi:10.1039/c4cc01251h

Mn(II)-containing coordination nanoparticles as highly efficient T(1) contrast agents for magnetic resonance imaging

Chem Commun (Camb). 2014 Jun 28;50(51):6740-3. doi: 10.1039/c4cc01251h.

Authors

Gabriella Paul¹, Yoann Prado, Nada Dia, Eric Rivière, Sophie Laurent, Mathieu Roch, Luce Vander Elst, Robert N Muller, Lucie Sancey, Pascal Perriat, Olivier Tillement, Talal Mallah, Laure Catala

Affiliation

¹ Institut de Chimie Moléculaire et des Matériaux d'Orsay, CNRS, Université Paris 11, 91405 Orsay, France. [email protected].

PMID: 24829060
DOI: 10.1039/c4cc01251h

Abstract

Large longitudinal relaxivities were observed in Mn(II)-containing Prussian blue analogue nanoparticles. At low concentrations and high field (7 T), a remarkable positive contrast enhancement was seen which exceeded that of clinical contrast agents and was attributed to the very large proportion of surface atoms of these coordination nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Contrast Media / chemical synthesis*
Drug Screening Assays, Antitumor
Ferrocyanides / chemistry
HEK293 Cells
Humans
Magnetic Resonance Imaging / methods*
Manganese Compounds / chemistry*
Manganese Compounds / pharmacology
Nanoparticles / chemistry*
Quantum Dots

Substances

Antineoplastic Agents
Contrast Media
Ferrocyanides
Manganese Compounds
ferric ferrocyanide