Extremes of age are associated with indeterminate QuantiFERON-TB gold assay results

J Clin Microbiol. 2014 Jul;52(7):2694-7. doi: 10.1128/JCM.00814-14. Epub 2014 May 14.

Abstract

Results from 3,263 QuantiFERON-TB Gold in-tube (QFT-GIT) assays were analyzed to determine the impact of age on test performance. The proportion of indeterminate results was significantly higher in pediatric and elderly (9.1% and 7.4%, respectively) than in adult (2.6%; chi-square test, P < 0.0001) patients. A detailed analysis of indeterminate QFT-GIT assay results is presented.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Interferon-gamma Release Tests / methods*
  • Male
  • Middle Aged
  • Sensitivity and Specificity
  • Tuberculosis / diagnosis*
  • Young Adult