Abstract
Purpose:
To investigate the prevalence of Toxoplasma gondii and Toxocara canis in patients with uveitis.
Method:
Patients with uveitis were examined. Serum antibodies to T. gondii and T. canis were tested by using enzyme-linked immunosorbent assay (ELISA). Polymerase chain reaction (PCR) was done using blood and aqueous humor (AH).
Results:
98 patients were enrolled. Mean age was 43.5 ± 13.2 years. Six patients were seropositive for T. gondii with the following pattern-anterior uveitis: 1; posterior uveitis with retinitis: 2; pan uveitis: 2. One patient had a positive result of PCR for T.gondii in AH, who showed pan uveitis. 23 patients were positive to serum IgG for T. canis with the following clinical manifestation-granuloma: 6; pigmented scar: 3; virtrits: 6-but none were PCR positive.
Conclusion:
T.gondii and T.canis are still one of the important causes of uveitis. Ocular toxocariasis is not an uncommon cause of uveitis even in adult.
Keywords:
Ocular toxocariasis; ocular toxoplasmosis; parasite; serologic test; uveitis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Animals
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Antibodies, Helminth / analysis
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Antibodies, Protozoan / analysis
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Aqueous Humor / parasitology
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Blotting, Western
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DNA, Helminth / analysis
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DNA, Protozoan / analysis
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Enzyme-Linked Immunosorbent Assay
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Eye Infections, Parasitic / diagnosis
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Eye Infections, Parasitic / epidemiology*
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Eye Infections, Parasitic / parasitology
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Female
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Follow-Up Studies
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Humans
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Male
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Middle Aged
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Polymerase Chain Reaction
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Prevalence
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Prospective Studies
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Republic of Korea / epidemiology
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Toxocara canis / genetics
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Toxocara canis / immunology
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Toxocara canis / isolation & purification*
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Toxocariasis
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Toxoplasma / genetics
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Toxoplasma / immunology
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Toxoplasma / isolation & purification*
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Toxoplasmosis, Ocular / diagnosis
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Toxoplasmosis, Ocular / epidemiology*
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Toxoplasmosis, Ocular / parasitology
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Uveitis, Posterior / diagnosis
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Uveitis, Posterior / epidemiology*
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Uveitis, Posterior / parasitology
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Young Adult
Substances
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Antibodies, Helminth
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Antibodies, Protozoan
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DNA, Helminth
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DNA, Protozoan