Next generation platforms for high-throughput biodosimetry

Radiat Prot Dosimetry. 2014 Jun;159(1-4):105-10. doi: 10.1093/rpd/ncu161. Epub 2014 May 17.

Abstract

Here the general concept of the combined use of plates and tubes in racks compatible with the American National Standards Institute/the Society for Laboratory Automation and Screening microplate formats as the next generation platforms for increasing the throughput of biodosimetry assays was described. These platforms can be used at different stages of biodosimetry assays starting from blood collection into microtubes organised in standardised racks and ending with the cytogenetic analysis of samples in standardised multiwell and multichannel plates. Robotically friendly platforms can be used for different biodosimetry assays in minimally equipped laboratories and on cost-effective automated universal biotech systems.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Automation, Laboratory*
  • Chromosome Aberrations / radiation effects*
  • Chromosomes, Human / radiation effects*
  • Clinical Laboratory Techniques / instrumentation*
  • Clinical Laboratory Techniques / methods
  • Cytogenetic Analysis / methods*
  • Dose-Response Relationship, Radiation
  • High-Throughput Screening Assays / instrumentation*
  • High-Throughput Screening Assays / methods
  • Humans
  • Image Processing, Computer-Assisted
  • Metaphase / radiation effects
  • Radiation Monitoring / methods*