Structural biology: a 'funny' cyclic dinucleotide receptor

Nat Chem Biol. 2014 Jun;10(6):413-4. doi: 10.1038/nchembio.1530.

Abstract

Deciphering the molecular basis of HCN channel regulation by cGMP leads to the serendipitous discovery of cyclic dinucleotides as potent inhibitors of I(f) current in the heart.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cyclic AMP / metabolism*
  • Cyclic GMP / analogs & derivatives*
  • Cyclic GMP / metabolism
  • Dinucleoside Phosphates / metabolism*
  • Humans
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels / metabolism*
  • Ion Channel Gating / physiology*
  • Muscle Proteins / metabolism*
  • Potassium Channels / metabolism*

Substances

  • Dinucleoside Phosphates
  • HCN4 protein, human
  • Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
  • Muscle Proteins
  • Potassium Channels
  • cyclic diadenosine phosphate
  • bis(3',5')-cyclic diguanylic acid
  • Cyclic AMP
  • Cyclic GMP