Abstract
The effects of sodium salts of medium-chain fatty acids, caprylate and caprate, on the penetration of a hydrophilic compound and a macromolecular compound across rabbit corneas in vitro were examined. Sodium caprylate (0.5 and 1% 2/v) marginally increased the corneal penetration of 6-carboxyfluorescein, a hydrophilic compound. However, it did not change the corneal penetration of FITC-dextran (mol.wt 4000). Sodium caprate (0.5 and 1% w/v) markedly increased the corneal penetration of these compounds.
MeSH terms
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Animals
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Biological Availability
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Caprylates / pharmacology
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Chondroitin Sulfates / pharmacology
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Cornea / metabolism*
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Decanoic Acids / pharmacology
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Dextrans / pharmacokinetics
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Electrophysiology
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Fatty Acids / pharmacology*
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Fluorescein-5-isothiocyanate* / analogs & derivatives*
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Fluoresceins / pharmacokinetics
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Hyaluronic Acid / pharmacology
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In Vitro Techniques
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Rabbits
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Stimulation, Chemical
Substances
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Caprylates
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Decanoic Acids
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Dextrans
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Fatty Acids
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Fluoresceins
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fluorescein isothiocyanate dextran
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6-carboxyfluorescein
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Hyaluronic Acid
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Chondroitin Sulfates
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Fluorescein-5-isothiocyanate
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octanoic acid