[The relevance of PET/CT for the surgical management of neuroendocrine neoplasms]

Chirurg. 2014 Jun;85(6):500-4. doi: 10.1007/s00104-013-2671-0.
[Article in German]

Abstract

Neuroendocrine neoplasms (NEN) are rare malignancies with a wide spectrum of metastatic potential which originate from the endocrine cells of the body and express somatostatin receptors. The (68)gallium somatostatin receptor positron emission tomography-computed tomography (PET/CT) technique is the most sensitive method of assessment of well-differentiated NENs and for the detection of cancer of unknown primary (CUP syndrome) NENs. Imaging with 18F-fluorodeoxyglucose (18F-FDG PET/CT) is indicated in poorly differentiated neuroendocrine carcinomas. The receptor-dependent imaging of NENs has a decisive impact on further management.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Fluorodeoxyglucose F18
  • Gallium Radioisotopes
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • Molecular Imaging / methods*
  • Multimodal Imaging / methods*
  • Neoplasms, Unknown Primary / diagnosis
  • Neoplasms, Unknown Primary / genetics
  • Neoplasms, Unknown Primary / pathology
  • Neoplasms, Unknown Primary / surgery
  • Neuroendocrine Tumors / diagnosis*
  • Neuroendocrine Tumors / genetics
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / surgery*
  • Positron-Emission Tomography / methods*
  • Receptors, Somatostatin
  • Sensitivity and Specificity
  • Somatostatin
  • Tomography, X-Ray Computed / methods*

Substances

  • Gallium Radioisotopes
  • Receptors, Somatostatin
  • Fluorodeoxyglucose F18
  • Somatostatin