Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

M H N Chagas; A L Eckeli; A W Zuardi; M A Pena-Pereira; M A Sobreira-Neto; E T Sobreira; M R Camilo; M M Bergamaschi; C H Schenck; J E C Hallak; V Tumas; J A S Crippa

doi:10.1111/jcpt.12179

Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

J Clin Pharm Ther. 2014 Oct;39(5):564-6. doi: 10.1111/jcpt.12179. Epub 2014 May 21.

Authors

M H N Chagas¹, A L Eckeli, A W Zuardi, M A Pena-Pereira, M A Sobreira-Neto, E T Sobreira, M R Camilo, M M Bergamaschi, C H Schenck, J E C Hallak, V Tumas, J A S Crippa

Affiliation

¹ Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil; INCT Translational Medicine (CNPq), São Paulo, Brazil.

PMID: 24845114
DOI: 10.1111/jcpt.12179

Abstract

What is known and objective: Cannabidiol (CBD) is the main non-psychotropic component of the Cannabis sativa plant. REM sleep behaviour disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming. We have described the effects of CBD in RBD symptoms in patients with Parkinson's disease.

Cases summary: Four patients treated with CBD had prompt and substantial reduction in the frequency of RBD-related events without side effects.

What is new and conclusion: This case series indicates that CBD is able to control the symptoms of RBD.

Keywords: Parkinson's disease; cannabidiol; rapid eye movement sleep behaviour disorder.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cannabidiol / therapeutic use*
Cannabis*
Humans
Male
Middle Aged
Parkinson Disease*
Phytotherapy*
REM Sleep Behavior Disorder / drug therapy*

Substances

Cannabidiol