Flow cytometric monitoring of the in vitro inhibition of the phosphorylation of CRKL and of SRC family kinases in patients with chronic myelogenous leukemia treated with tyrosine kinase inhibitors

Int J Lab Hematol. 2015 Feb;37(1):e11-5. doi: 10.1111/ijlh.12258. Epub 2014 May 21.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / antagonists & inhibitors*
  • Antineoplastic Agents / pharmacology*
  • Antineoplastic Agents / therapeutic use
  • Flow Cytometry
  • Humans
  • In Vitro Techniques
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / metabolism*
  • Nuclear Proteins / antagonists & inhibitors*
  • Phosphorylation / drug effects
  • Protein Kinase Inhibitors / pharmacology*
  • Protein Kinase Inhibitors / therapeutic use
  • src-Family Kinases / antagonists & inhibitors*

Substances

  • Adaptor Proteins, Signal Transducing
  • Antineoplastic Agents
  • CRKL protein
  • Nuclear Proteins
  • Protein Kinase Inhibitors
  • src-Family Kinases