Variation in the fat mass and obesity-related (FTO) genotype is not associated with body fatness in infants, but possibly with their length

P Henriksson; M Löf; P Söderkvist; E Forsum

doi:10.1111/ijpo.231

Variation in the fat mass and obesity-related (FTO) genotype is not associated with body fatness in infants, but possibly with their length

Pediatr Obes. 2014 Oct;9(5):e112-5. doi: 10.1111/ijpo.231. Epub 2014 May 21.

Authors

P Henriksson¹, M Löf, P Söderkvist, E Forsum

Affiliation

¹ Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

PMID: 24846219
DOI: 10.1111/ijpo.231

Abstract

Background: Data relating variation at the fat mass and obesity-related (FTO) locus (rs9939609) to fat mass in infancy are inconclusive.

Objective: To study relationships between FTO genotype and infant size (at 1 and 12 weeks and at 1 year of age) and body composition (at 1 and 12 weeks).

Methods: Body composition was assessed using air displacement plethysmography in 207 infants. FTO was genotyped using the TaqMan assay.

Results: The number of risk alleles was related to length at 1 and 12 weeks (P = 0.007-0.033) but not to fat mass. The relationship to length was stronger in boys than in girls.

Conclusions: Our results suggest that the FTO genotype is not related during infancy to fat mass but is related to length in boys but not in girls.

Keywords: Body composition; FTO; fat mass; infant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adiposity
Alleles
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Analysis of Variance
Body Composition
Body Fat Distribution*
Body Height*
Body Mass Index
Female
Genotype
Humans
Infant
Infant, Newborn
Male
Obesity / genetics*
Polymorphism, Single Nucleotide / genetics
Proteins / genetics*
Sex Distribution

Substances

Proteins
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
FTO protein, human