Acute pancreatitis in six non-transplanted uraemic children. A co-operative study from the French Society of Paediatric Nephrology

Pediatr Nephrol. 1988 Oct;2(4):431-5. doi: 10.1007/BF00853437.

Abstract

Ten clinical episodes of acute pancreatitis (AP) occurred in six patients (mean age 10 years, range 3-15 years) with chronic renal failure (CRF) during a 9-year period (1977-1986). The underlying cause of CRF was vesicoureteral reflux (2); urethral valves (1); ureterohydronephrosis (1); nephronopthisis (1) and a haemolytic uraemic syndrome which occurred 12 years before (1). In all patients a diagnosis of AP was established both on clinical grounds and with a serum amylase level of greater than 600 IU/l. In 3 patients laparotomy was performed because of suspected appendicitis. All patients required exclusive parenteral feeding (mean duration 25 days) and 2 patients had a partial pancreatectomy. No patient developed pancreatic pseudocysts, 2 patients experienced one relapse (3 and 21 months later) and 1 patient had two relapses and died. Mean duration of follow up was 3 years (range 1-10 years). Possible aetiological factors were: choledochal cyst (1); parotitis without a rise in mumps antibodies (1); familial dyslipidaemia but without AP in other family members (1), and aluminium intoxication with hypercalcaemia and convulsive encephalopathy treated with valproic acid in 1 patient. Severe hyperparathyroidism with radiological signs was absent in all patients. Transplantation had been performed either before AP in 2 patients (1 and 3 years before AP) or had followed AP in 1 patient (7 years after) without occurrence or relapse of AP.

Publication types

  • Case Reports

MeSH terms

  • Acute Disease
  • Adolescent
  • Amylases / blood
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Kidney Transplantation / adverse effects
  • Male
  • Pancreatitis / complications*
  • Pancreatitis / diagnosis
  • Pancreatitis / etiology
  • Peritoneal Dialysis, Continuous Ambulatory / adverse effects
  • Uremia / complications*
  • Uremia / surgery
  • Uremia / therapy

Substances

  • Amylases