Extensive cerebral white matter involvement in a patient with NMO spectrum disorder

Xavier Ayrignac; Clarisse Carra Dalière; Elodie Nerrant; Thierry Vincent; Jérôme De Seze; Pierre Labauge

doi:10.1177/1352458514536253

Extensive cerebral white matter involvement in a patient with NMO spectrum disorder

Mult Scler. 2014 Sep;20(10):1401-3. doi: 10.1177/1352458514536253. Epub 2014 May 22.

Authors

Xavier Ayrignac¹, Clarisse Carra Dalière², Elodie Nerrant², Thierry Vincent², Jérôme De Seze³, Pierre Labauge²

Affiliations

¹ CHU Montpellier, France [email protected].
² CHU Montpellier, France.
³ CHRU Strasbourg, France.

PMID: 24852925
DOI: 10.1177/1352458514536253

Abstract

Abnormal brain MRI has been described in up to 60% of patients with NMO patients. However, white matter T2 hyperintensities have been rarely observed. We report the case of a 49-year-old woman with long-lasting neuromyelitis optica (NMO) spectrum disorder and diffuse cerebral white matter T2-weighted hyperintensities. Our case suggests that some NMO patients can progressively develop l extensive cerebral involvement.

Keywords: Devic’s syndrome; Neuromyelitis Optica; white matter disease.

Publication types

Case Reports

MeSH terms

Aquaporin 4 / immunology
Autoantibodies / blood
Biomarkers / blood
Disease Progression
Female
Humans
Immunosuppressive Agents / therapeutic use
Leukoencephalopathies / diagnosis*
Leukoencephalopathies / pathology
Magnetic Resonance Imaging*
Middle Aged
Neuromyelitis Optica / blood
Neuromyelitis Optica / diagnosis*
Neuromyelitis Optica / drug therapy
Neuromyelitis Optica / immunology
Neuromyelitis Optica / pathology
Predictive Value of Tests
Time Factors
Treatment Outcome
White Matter / pathology*

Substances

AQP4 protein, human
Aquaporin 4
Autoantibodies
Biomarkers
Immunosuppressive Agents