Blood-brain barrier: a dual life of MFSD2A?

Zhen Zhao; Berislav V Zlokovic

doi:10.1016/j.neuron.2014.05.012

Blood-brain barrier: a dual life of MFSD2A?

Neuron. 2014 May 21;82(4):728-30. doi: 10.1016/j.neuron.2014.05.012.

Authors

Zhen Zhao¹, Berislav V Zlokovic²

Affiliations

¹ Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
² Zilkha Neurogenetic Institute and Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. Electronic address: [email protected].

Abstract

Two recent papers in Nature, Ben-Zvi et al. (2014) and Nguyen et al. (2014), report a surprising dual role for the blood-brain barrier transporter MFSD2A in both establishing BBB integrity and in uptake of the fatty acid DHA.

Publication types

Comment

MeSH terms

Animals
Blood-Brain Barrier / embryology*
Blood-Brain Barrier / physiology*
Brain / metabolism*
Docosahexaenoic Acids / metabolism*
Female
Male
Membrane Transport Proteins / metabolism*

Substances

Membrane Transport Proteins
Docosahexaenoic Acids

Abstract

Publication types

MeSH terms

Substances

Grants and funding