Abstract
In the first part of this paper, we show that intraperitoneal injection of adenosine into newborn mice causes multiple neural crest tumors, neural crest hyperplasia, and heterotopic melanin pigmentation. In the second part, we review published data to propose (1) that microtubule proteins, phosphorylated through the action of calmodulin-dependent kinase and cyclic adenosine monophosphate and the adenosine A2 receptor of neural crest cells, may participate in neurotransmission and (2) that at least some neural crest tumors may be associated with disorders of neurotransmission in embryonic neural crest cells.
MeSH terms
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Adenosine*
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Adrenal Gland Neoplasms / chemically induced
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Adrenal Gland Neoplasms / pathology
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Animals
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Animals, Newborn
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Bone Neoplasms / chemically induced
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Bone Neoplasms / pathology
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Carotid Body Tumor / chemically induced
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Carotid Body Tumor / pathology
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Digestive System Neoplasms / chemically induced
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Digestive System Neoplasms / pathology
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Melanins / metabolism
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Melanoma / chemically induced
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Melanoma / pathology
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Mice
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Mice, Inbred ICR
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Muscular Diseases / chemically induced
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Muscular Diseases / pathology
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Neoplasms, Experimental / chemically induced*
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Neoplasms, Experimental / pathology
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Nervous System Neoplasms / chemically induced
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Nervous System Neoplasms / pathology
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Neural Crest / pathology*
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Neurofibroma / chemically induced
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Neurofibroma / pathology
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Peripheral Nervous System Neoplasms / chemically induced
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Peripheral Nervous System Neoplasms / pathology
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Pheochromocytoma / chemically induced
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Pheochromocytoma / pathology
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Pigmentation Disorders / chemically induced
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Skin Neoplasms / chemically induced
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Skin Neoplasms / pathology
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Tongue Neoplasms / chemically induced
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Tongue Neoplasms / pathology