Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, and it has a significant prevalence in the male population (X chromosome linked). The purpose of this study was to estimate the frequency of impaired fasting glucose and diabetes among G6PD-deficient persons in Manaus, Brazil, an area in the Western Brazilian Amazon to which malaria is endemic. Glucose-6-phosphate dehydrogenase-deficient males had more impaired fasting glucose and diabetes. This feature could be used as a screening tool for G6PD-deficient persons who are unable to use primaquine for the radical cure of Plasmodium vivax malaria.
© The American Society of Tropical Medicine and Hygiene.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Antimalarials
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Blood Glucose / metabolism*
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Brazil / epidemiology
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Child
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Contraindications
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Diabetes Complications
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Diabetes Mellitus / drug therapy
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Diabetes Mellitus / epidemiology*
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Diabetes Mellitus / parasitology
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Fasting
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Glucosephosphate Dehydrogenase Deficiency / complications
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Glucosephosphate Dehydrogenase Deficiency / drug therapy
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Glucosephosphate Dehydrogenase Deficiency / epidemiology*
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Glucosephosphate Dehydrogenase Deficiency / parasitology
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Humans
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Malaria, Vivax / complications
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Malaria, Vivax / drug therapy
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Malaria, Vivax / epidemiology*
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Malaria, Vivax / parasitology
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Male
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Middle Aged
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Plasmodium vivax*
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Prevalence
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Primaquine
Substances
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Antimalarials
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Blood Glucose
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Primaquine