Downregulation of neuregulin 1-ErbB4 signaling and antidepressant properties of ketamine: ErbB4 expressing pyramidal neurons may play a role

J Mol Neurosci. 2015 Feb;55(2):372-3. doi: 10.1007/s12031-014-0340-5. Epub 2014 May 30.

Abstract

We comment on a recent paper of Wang et al. (J Mol Neurosci, 2014), who have shown that ketamine reduces neuregulin1-ErbB4 signaling in interneurons.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antidepressive Agents / pharmacology*
  • Brain / metabolism*
  • Depression / metabolism*
  • Interneurons / metabolism*
  • Ketamine / pharmacology*
  • Male
  • Neuregulin-1 / metabolism*
  • Receptor, ErbB-4 / metabolism*

Substances

  • Antidepressive Agents
  • Neuregulin-1
  • Ketamine
  • Receptor, ErbB-4