Viral hemorrhagic fever cases in the country of Georgia: Acute Febrile Illness Surveillance Study results

Am J Trop Med Hyg. 2014 Aug;91(2):246-8. doi: 10.4269/ajtmh.13-0460. Epub 2014 Jun 2.

Abstract

Minimal information is available on the incidence of Crimean-Congo hemorrhagic fever (CCHF) virus and hantavirus infections in Georgia. From 2008 to 2011, 537 patients with fever ≥ 38°C for ≥ 48 hours without a diagnosis were enrolled into a sentinel surveillance study to investigate the incidence of nine pathogens, including CCHF virus and hantavirus. Of 14 patients with a hemorrhagic fever syndrome, 3 patients tested positive for CCHF virus immunoglobulin M (IgM) antibodies. Two of the patients enrolled in the study had acute renal failure. These 2 of 537 enrolled patients were the only patients in the study positive for hantavirus IgM antibodies. These results suggest that CCHF virus and hantavirus are contributing causes of acute febrile syndromes of infectious origin in Georgia. These findings support introduction of critical diagnostic approaches and confirm the need for additional surveillance in Georgia.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acute Kidney Injury / epidemiology*
  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / immunology
  • Acute Kidney Injury / virology
  • Adolescent
  • Adult
  • Antibodies, Viral / blood*
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay
  • Epidemiological Monitoring
  • Female
  • Georgia / epidemiology
  • Hantavirus Infections / complications
  • Hantavirus Infections / epidemiology*
  • Hantavirus Infections / immunology
  • Hantavirus Infections / virology
  • Hemorrhagic Fever Virus, Crimean-Congo / physiology
  • Hemorrhagic Fever, Crimean / epidemiology*
  • Hemorrhagic Fever, Crimean / immunology
  • Hemorrhagic Fever, Crimean / virology
  • Humans
  • Immunoglobulin M / blood*
  • Male
  • Orthohantavirus / pathogenicity
  • Orthohantavirus / physiology

Substances

  • Antibodies, Viral
  • Immunoglobulin M