Bone marrow stromal cell-fueled multiple myeloma growth and osteoclastogenesis are sustained by protein kinase CK2

Leukemia. 2014 Oct;28(10):2094-7. doi: 10.1038/leu.2014.178. Epub 2014 Jun 4.

Authors

S Manni¹, D Toscani², E Mandato¹, A Brancalion¹, L Quotti Tubi¹, P Macaccaro¹, A Cabrelle³, F Adami⁴, R Zambello¹, C Gurrieri¹, G Semenzato¹, N Giuliani², F Piazza¹

Affiliations

¹ 1] Department of Medicine, Hematology and Clinical Immunology Branch, University of Padua, Padua, Italy [2] Venetian Institute of Molecular Medicine, Padua, Italy.
² Department of Clinical and Experimental Medicine, Hematology, University of Parma, Parma, Italy.
³ Venetian Institute of Molecular Medicine, Padua, Italy.
⁴ Department of Medicine, Hematology and Clinical Immunology Branch, University of Padua, Padua, Italy.

PMID: 24897506
DOI: 10.1038/leu.2014.178

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemistry
Bone Marrow Cells / cytology*
Casein Kinase II / metabolism*
Cell Survival
Cytokines / metabolism
Gene Expression Regulation, Enzymologic*
Gene Expression Regulation, Neoplastic*
Gene Silencing
Humans
Interleukin-6 / metabolism
Multiple Myeloma / metabolism*
Osteoblasts / cytology
Osteoclasts / cytology*
Phosphorylation
Receptors, CXCR4 / metabolism
Stromal Cells / cytology
Tumor Necrosis Factor-alpha / metabolism

Substances

Antineoplastic Agents
CXCR4 protein, human
Cytokines
Interleukin-6
Receptors, CXCR4
Tumor Necrosis Factor-alpha
Casein Kinase II