Competitive endogenous RNAs cannot alter microRNA function in vivo

Jennifer A Broderick; Phillip D Zamore

doi:10.1016/j.molcel.2014.05.023

Competitive endogenous RNAs cannot alter microRNA function in vivo

Mol Cell. 2014 Jun 5;54(5):711-3. doi: 10.1016/j.molcel.2014.05.023.

Authors

Jennifer A Broderick¹, Phillip D Zamore²

Affiliations

¹ RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, and Howard Hughes Medical Institute, University of Massachusetts Medical School, ASC4-2053, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: [email protected].
² RNA Therapeutics Institute, Department of Biochemistry and Molecular Pharmacology, and Howard Hughes Medical Institute, University of Massachusetts Medical School, ASC4-2053, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: [email protected].

PMID: 24905003
DOI: 10.1016/j.molcel.2014.05.023

Abstract

In this issue of Molecular Cell, Denzler et al. (2014) report a quantitative study of microRNA function in adult mouse liver, suggesting that the natural abundance of miRNAs and their binding sites generally excludes the previously proposed regulation of miRNAs by competitive endogenous RNAs (ceRNAs).

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Male
MicroRNAs / genetics*
RNA Interference*

Substances

MicroRNAs
Mirn122 microRNA, mouse

Grants and funding

Howard Hughes Medical Institute/United States