Delivering three punches to knockout intracellular bacteria

Emilie Narni-Mancinelli; Eric Vivier

doi:10.1016/j.cell.2014.05.023

Delivering three punches to knockout intracellular bacteria

Cell. 2014 Jun 5;157(6):1251-1252. doi: 10.1016/j.cell.2014.05.023.

Authors

Emilie Narni-Mancinelli¹, Eric Vivier²

Affiliations

¹ Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, 13288 Marseille, France; INSERM U1104, 13288 Marseille, France; CNRS UMR7280, 13288 Marseille, France.
² Centre d'Immunologie de Marseille-Luminy, UM2 Aix-Marseille Université, 13288 Marseille, France; INSERM U1104, 13288 Marseille, France; CNRS UMR7280, 13288 Marseille, France; Service d'Immunologie, Assistance Publique-Hôpitaux de Marseille, Hôpital de la Conception, 13285 Marseille, France. Electronic address: [email protected].

PMID: 24906142
DOI: 10.1016/j.cell.2014.05.023

Abstract

Cytotoxic lymphocytes kill bacteria-infected cells, but the mechanisms at work remain unclear. Walch et al. show that these lymphocytes deliver a toxic molecular trio in a two-step process, penetrating first the infected cells and then delivering bactericidal granzymes into the intracytoplasmic bacteria.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Antigens, Differentiation, T-Lymphocyte / metabolism*
Bacterial Infections / immunology*
Escherichia coli*
Humans
Leukocytes, Mononuclear / immunology*
Listeria monocytogenes*
Staphylococcus aureus*

Substances

Antigens, Differentiation, T-Lymphocyte
GNLY protein, human