HIV-1 superinfection with a triple-class drug-resistant strain in a patient successfully controlled with antiretroviral treatment

AIDS. 2014 Jul 31;28(12):1840-4. doi: 10.1097/QAD.0000000000000342.

Abstract

We report a case of HIV-1 superinfection (HSI) with a clade B, triple-class resistant virus in a patient successfully controlling viremia with continuous combination antiretroviral therapy started 8 years earlier during primary HIV infection. The course of HIV infection prior to HSI was monitored in both the source partner and recipient (8 and 11 years, respectively) and 4 years following HSI. This case report demonstrates re-infection with HIV-1 despite effective combination antiretroviral therapy.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-Retroviral Agents / therapeutic use*
  • Antiretroviral Therapy, Highly Active / methods*
  • Drug Resistance, Multiple, Viral*
  • Genotype
  • HIV Infections / diagnosis
  • HIV Infections / drug therapy*
  • HIV Infections / virology*
  • HIV-1 / drug effects*
  • HIV-1 / isolation & purification
  • Humans
  • Male
  • Molecular Sequence Data
  • Sequence Analysis, DNA
  • Superinfection / diagnosis*
  • Treatment Outcome

Substances

  • Anti-Retroviral Agents

Associated data

  • GENBANK/KC797171
  • GENBANK/KC797172
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