CD8+/CD161++ mucosal-associated invariant T-cell levels in the colon are restored on long-term antiretroviral therapy and correlate with CD8+ T-cell immune activation

AIDS. 2014 Jul 17;28(11):1690-2. doi: 10.1097/QAD.0000000000000351.

Abstract

Mucosal-associated invariant T (MAIT) cells are tissue-homing T cells recently implicated in HIV pathogenesis. We found that the proportion of MAIT cell in blood and colon of HIV+ patients are reduced in untreated infection. Antiretroviral therapy restored colonic but not blood MAIT cell percentages. We observed a negative correlation between colonic MAIT cells and T-cell activation in blood and suggest mucosal MAIT cell depletion may contribute to systemic immune activation in HIV infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Anti-Retroviral Agents / therapeutic use*
  • CD8-Positive T-Lymphocytes / chemistry
  • CD8-Positive T-Lymphocytes / immunology*
  • Colon / immunology*
  • Female
  • HIV Infections / drug therapy*
  • HIV Infections / immunology
  • Humans
  • Intestinal Mucosa / immunology*
  • Male
  • Middle Aged
  • NK Cell Lectin-Like Receptor Subfamily B / analysis*
  • T-Lymphocyte Subsets / chemistry
  • T-Lymphocyte Subsets / immunology*

Substances

  • Anti-Retroviral Agents
  • KLRB1 protein, human
  • NK Cell Lectin-Like Receptor Subfamily B