Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Alice C Eziefula; Helmi Pett; Lynn Grignard; Salome Opus; Moses Kiggundu; Moses R Kamya; Shunmay Yeung; Sarah G Staedke; Teun Bousema; Chris Drakeley

doi:10.1128/AAC.02889-14

Glucose-6-phosphate dehydrogenase status and risk of hemolysis in Plasmodium falciparum-infected African children receiving single-dose primaquine

Antimicrob Agents Chemother. 2014 Aug;58(8):4971-3. doi: 10.1128/AAC.02889-14. Epub 2014 Jun 9.

Authors

Affiliations

¹ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom.
² Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
³ Infectious Diseases Research Collaboration, Kampala, Uganda.
⁴ Infectious Diseases Research Collaboration, Kampala, Uganda Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda.
⁵ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom Department of Medical Microbiology, Radboud University Medical Center, Nijmegen, The Netherlands.
⁶ Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom [email protected].

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) enzyme function and genotype were determined in Ugandan children with uncomplicated falciparum malaria enrolled in a primaquine trial after exclusion of severe G6PD deficiency by fluorescent spot test. G6PD A- heterozygotes and hemizygotes/homozygotes experienced dose-dependent lower hemoglobin concentrations after treatment. No severe anemia was observed.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Antimalarials / therapeutic use*
Child
Child, Preschool
Double-Blind Method
Drug Administration Schedule
Female
Genotype
Glucosephosphate Dehydrogenase / genetics*
Hemoglobins / metabolism*
Hemolysis
Heterozygote
Homozygote
Humans
Malaria, Falciparum / drug therapy*
Malaria, Falciparum / enzymology
Malaria, Falciparum / genetics
Malaria, Falciparum / parasitology
Male
Plasmodium falciparum / drug effects
Plasmodium falciparum / physiology
Primaquine / therapeutic use*
Risk
Uganda

Substances

Antimalarials
Hemoglobins
Glucosephosphate Dehydrogenase
glucose-6-phosphate dehydrogenase A-
Primaquine

Abstract

Publication types

MeSH terms

Substances

Grants and funding