Snail and Slug mediate tamoxifen resistance in breast cancer cells through activation of EGFR-ERK independent of epithelial-mesenchymal transition

J Mol Cell Biol. 2014 Aug;6(4):352-4. doi: 10.1093/jmcb/mju019. Epub 2014 Jun 10.

Authors

Yan Jiang¹, Xiaotong Zhao¹, Qian Xiao¹, Qingbo Liu¹, Keshuo Ding², Fei Yu¹, Rui Zhang¹, Tao Zhu², Gaoxiang Ge³

Affiliations

¹ State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
² Hefei National Laboratory for Physical Sciences, Hefei, Anhui 230027, China.
³ State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China Cancer Research Center, Shanghai Xu-Hui Central Hospital, Shanghai Clinical Center, Chinese Academy of Sciences, Shanghai 200031, China [email protected].

PMID: 24916398
DOI: 10.1093/jmcb/mju019

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents, Hormonal / pharmacology
Breast Neoplasms / genetics
Breast Neoplasms / metabolism
Breast Neoplasms / pathology*
Drug Resistance, Neoplasm*
Epithelial-Mesenchymal Transition*
ErbB Receptors / genetics
ErbB Receptors / metabolism*
Female
Humans
Mitogen-Activated Protein Kinase 1 / genetics
Mitogen-Activated Protein Kinase 1 / metabolism*
Mitogen-Activated Protein Kinase 3 / genetics
Mitogen-Activated Protein Kinase 3 / metabolism*
Snail Family Transcription Factors
Tamoxifen / pharmacology*
Transcription Factors / genetics
Transcription Factors / metabolism*
Tumor Cells, Cultured

Substances

Antineoplastic Agents, Hormonal
SNAI1 protein, human
Snail Family Transcription Factors
Transcription Factors
Tamoxifen
EGFR protein, human
ErbB Receptors
MAPK1 protein, human
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3