Low-dose high-pitch CT angiography of the supraaortic arteries using sinogram-affirmed iterative reconstruction

PLoS One. 2014 Jun 11;9(6):e99832. doi: 10.1371/journal.pone.0099832. eCollection 2014.

Abstract

Objective: To prospectively evaluate image quality and radiation dose using a low-dose computed tomography angiography protocol and iterative image reconstruction for high-pitch dual-source CT-angiography (DSCTA) of the supraaortic arteries.

Material and methods: DSCTA was performed in 42 patients, using either 120 kVp tube voltage, 120 mAS tube current, 2.4 pitch and filtered back projection, or 100 kVp tube voltage, 100 mAs tube current, 3.2 pitch, and sinogram affirmed iterative reconstruction. Measurements of vessel attenuation, of the contrast-to-noise ratio (CNR) and the signal-to-noise ratio (SNR) were performed to objectively evaluate image quality. Two readers evaluated subjective image quality and image noise, using a four-point scale. Effective dose was used to compare the differences in radiation dose.

Results: Low-dose protocol application showed significantly higher vessel opacification (p = 0.013), and non-significantly higher CNR and SNR values. There was no difference in the subjective image quality and image noise reading between the protocols. Effective dose was significantly lower using the low-dose protocol (1.29 ± 0.21 mSv vs. 2.92 ± 0.72 mSv; p < 0.001).

Conclusion: The combined use of reduced tube voltage, reduced tube current, and iterative reconstruction reduces radiation dose by 55.4% in high-pitch DSCTA of the supraaortic arteries without impairment of image quality.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Angiography / methods*
  • Arteries / diagnostic imaging*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Radiation Dosage
  • Radionuclide Imaging
  • Signal-To-Noise Ratio
  • Tomography, X-Ray Computed / methods*

Grants and funding

The authors have no support or funding to report.