Transition-metal-assisted radical/radical cross-coupling: a new strategy to the oxidative C(sp3)-H/N-H cross-coupling

Org Lett. 2014 Jun 20;16(12):3404-7. doi: 10.1021/ol501485f. Epub 2014 Jun 12.

Abstract

A transition-metal-assisted oxidative C(sp(3))-H/N-H cross-coupling reaction of N-alkoxyamides with aliphatic hydrocarbons is described. During the reaction, nitrogen radicals were generated from the oxidation of N-alkoxyamides. Experiments and DFT calculations revealed that transition-metal catalyst could lower the reactivity of the generated nitrogen radical by the coordination of the transition metal, which allowed the selective radical/radical cross-coupling with the transient sp(3) carbon radical to construct C(sp(3))--N bonds. Various C(sp(3))-H bonds could be transformed into C(sp(3))-N bonds through this radical amidation strategy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry*
  • Catalysis
  • Molecular Structure
  • Nitrogen / chemistry
  • Oxidation-Reduction
  • Transition Elements / chemistry*

Substances

  • Amides
  • Transition Elements
  • Nitrogen