Bisphosphonate-induced osteonecrosis of the maxilla presenting as a cicatricial ectropion

Orbit. 2014 Oct;33(5):369-71. doi: 10.3109/01676830.2013.814683. Epub 2014 Jun 12.

Abstract

A 63-year-old gentleman, who was being treated with bisphosphonates for multiple myeloma, presented with a cicatricial ectropion of the lower eyelid, without exposure keratopathy. A CT scan demonstrated extensive destruction of bone with an infraorbital fracture surrounded by sclerotic bony changes. The patient was managed conservatively with discontinuation of bisphosphonate therapy and topical ocular lubricants. The patient's condition remained unchanged a year after this initial management.

Keywords: Bisphosphonate; ectropion; osteonecrosis.

Publication types

  • Case Reports

MeSH terms

  • Bone Density Conservation Agents / adverse effects*
  • Diphosphonates / adverse effects*
  • Ectropion / chemically induced*
  • Ectropion / diagnosis
  • Eyelids / pathology
  • Humans
  • Male
  • Maxillary Diseases / chemically induced*
  • Maxillary Diseases / diagnostic imaging
  • Middle Aged
  • Multiple Myeloma / drug therapy
  • Osteonecrosis / chemically induced*
  • Osteonecrosis / diagnostic imaging
  • Tomography, X-Ray Computed

Substances

  • Bone Density Conservation Agents
  • Diphosphonates