Detection of glutamate and acetylcholine with organic electrochemical transistors based on conducting polymer/platinum nanoparticle composites

Adv Mater. 2014 Aug 27;26(32):5658-64. doi: 10.1002/adma.201401608. Epub 2014 Jun 13.

Abstract

The aim of the study is to open a new scope for organic electrochemical transistors based on PEDOT:PSS, a material blend known for its stability and reliability. These devices can leverage molecular electrocatalysis by incorporating small amounts of nano-catalyst during the transistor manufacturing (spin coating). This methodology is very simple to implement using the know-how of nanochemistry and results in efficient enzymatic activity transduction, in this case utilizing choline oxidase and glutamate oxidase.

Keywords: PEDOT:PSS; bioelectronics; electrochemical transistors; neurotransmitters; platinum nanoparticles.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholine / analysis
  • Alcohol Oxidoreductases / chemistry
  • Catalysis
  • Electrochemical Techniques / instrumentation*
  • Electrochemical Techniques / methods*
  • Glutamic Acid / analysis
  • Hydrogen Peroxide / chemistry
  • Metal Nanoparticles / chemistry*
  • Microscopy, Electron, Transmission
  • Platinum Compounds / chemistry*
  • Polymers / chemistry*
  • Sensitivity and Specificity
  • Transistors, Electronic*

Substances

  • Platinum Compounds
  • Polymers
  • Glutamic Acid
  • Hydrogen Peroxide
  • Alcohol Oxidoreductases
  • choline oxidase
  • Acetylcholine