Abstract
Mannose is a simple sugar with a complex life. It is a welcome therapy for genetic and acquired human diseases, but it kills honeybees and blinds baby mice. It could cause diabetic complications. Mannose chemistry, metabolism, and metabolomics in cells, tissues and mammals can help explain these multiple systemic effects. Mannose has good, bad or ugly outcomes depending on its steady state levels and metabolic flux. This review describes the role of mannose at cellular level and its impact on organisms.
Keywords:
Congenital disorders of glycosylation; Mannose; Metabolism; N-glycosylation; Phosphomannomutase; Phosphomannose isomerase.
Copyright © 2014 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Congenital Disorders of Glycosylation / diet therapy
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Congenital Disorders of Glycosylation / genetics
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Congenital Disorders of Glycosylation / metabolism
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Dietary Carbohydrates / administration & dosage
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Dietary Carbohydrates / metabolism
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Disease Models, Animal
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Female
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Gene Knockdown Techniques
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Humans
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Mannose / administration & dosage
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Mannose / chemistry
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Mannose / metabolism*
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Mannose-6-Phosphate Isomerase / deficiency
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Mannose-6-Phosphate Isomerase / genetics
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Mannose-6-Phosphate Isomerase / metabolism
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Metabolic Flux Analysis
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Metabolic Networks and Pathways
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Metabolomics
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Mice
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Phosphotransferases (Phosphomutases) / deficiency
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Phosphotransferases (Phosphomutases) / genetics
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Phosphotransferases (Phosphomutases) / metabolism
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Polysaccharides / chemistry
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Polysaccharides / metabolism
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Pregnancy
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Zebrafish
Substances
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Dietary Carbohydrates
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Polysaccharides
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Mannose-6-Phosphate Isomerase
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Phosphotransferases (Phosphomutases)
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Mannose