Abstract
IL-21 regulates the activity and number of IL-10-producing regulatory B cells (B10 cells) that modulate immune responses and limit diverse autoimmune diseases. A new study demonstrates that IL-35 has a similar function. Identifying regulatory circuits that control B10-cell function in vivo might open the door to future treatments for autoimmune diseases.
Publication types
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Research Support, N.I.H., Intramural
MeSH terms
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Animals
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Autoimmune Diseases / blood
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Autoimmune Diseases / immunology*
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Autoimmune Diseases / therapy
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Autoimmunity*
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B-Lymphocytes, Regulatory / metabolism*
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Biomarkers / blood
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Disease Models, Animal
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Humans
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Inflammation / immunology
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Interleukin-10 / blood*
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Interleukins / blood*
Substances
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Biomarkers
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Interleukins
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interleukin-35, human
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Interleukin-10
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interleukin-21