Pharmacology of pain

Reumatismo. 2014 Jun 6;66(1):14-7. doi: 10.4081/reumatismo.2014.759.

Abstract

This article discusses the mechanisms of action of the main drugs used to treat pain, in particular inflammatory pain. The drugs are described following a classification based on the steps of pain processing that they primarily affect.

Publication types

  • Review

MeSH terms

  • Analgesics / pharmacology
  • Analgesics / therapeutic use*
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Brain / physiopathology
  • Central Nervous System Sensitization / drug effects
  • Central Nervous System Sensitization / physiology
  • Chronic Pain / drug therapy*
  • Chronic Pain / physiopathology
  • Drug Tolerance
  • Humans
  • NAV1.8 Voltage-Gated Sodium Channel / drug effects
  • NAV1.8 Voltage-Gated Sodium Channel / physiology
  • Nerve Fibers, Unmyelinated / drug effects
  • Nerve Fibers, Unmyelinated / physiology
  • Neural Conduction / drug effects
  • Neural Conduction / physiology
  • Nociceptors / physiology
  • Pain Management
  • Pain Perception / physiology
  • Posterior Horn Cells / drug effects
  • Posterior Horn Cells / physiology
  • Prostaglandins / physiology
  • Receptors, Opioid / drug effects
  • Receptors, Opioid / physiology
  • TRPV Cation Channels / drug effects
  • TRPV Cation Channels / physiology

Substances

  • Analgesics
  • Anti-Inflammatory Agents
  • NAV1.8 Voltage-Gated Sodium Channel
  • Prostaglandins
  • Receptors, Opioid
  • SCN10A protein, human
  • TRPV Cation Channels
  • TRPV1 protein, human