The effects of norepinephrine depletion on cerebral blood flow in the rat

Brain Res. 1989 Jan 16;477(1-2):378-81. doi: 10.1016/0006-8993(89)91431-5.

Abstract

Cerebral blood flow (CBF) was measured by [14C]butanol indicator fractionation in 10 rats given intraventricular injections of 6-hydroxydopamine (6-OHDA) compared to 8 saline-injected controls. Rats treated with 6-OHDA displayed an 83% reduction in cortical norepinephrine (NE) levels. CBF was significantly increased in 6-OHDA-treated rats compared to controls (average whole brain blood flow of 126.0 +/- 8.3 and 97.1 +/- 10.6 ml.min-1.10(-2)g-1 respectively, P less than 0.05). These studies suggest that noradrenergic innervation of the brain and cerebral microvasculature exerts a moderating effect on resting CBF.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Butanols / metabolism
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / physiology
  • Cerebral Ventricles / drug effects
  • Cerebral Ventricles / physiology
  • Cerebrovascular Circulation* / drug effects
  • Dopamine / physiology*
  • Functional Laterality
  • Hydroxydopamines / pharmacology
  • Male
  • Norepinephrine / physiology*
  • Oxidopamine
  • Pargyline / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Reference Values

Substances

  • Butanols
  • Hydroxydopamines
  • Oxidopamine
  • Pargyline
  • Dopamine
  • Norepinephrine