Abstract
Recombinant human tumor necrosis factor alpha (rHuTNF-alpha) administered intravenously to mice resulted in enhanced resistance to a lethal challenge infection of Listeria monocytogenes given 24 h later. The observed protection was lost following treatment of the rHuTNF-alpha preparations with rabbit polyclonal antibody rHuTNF-alpha but not with normal rabbit immunoglobulin G.
MeSH terms
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Animals
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Antigen-Antibody Reactions
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Lipopolysaccharides / pharmacology
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Listeria monocytogenes
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Listeriosis / physiopathology
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Listeriosis / prevention & control*
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Mice
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Recombinant Proteins / therapeutic use
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Tumor Necrosis Factor-alpha / immunology
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Tumor Necrosis Factor-alpha / therapeutic use*
Substances
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Lipopolysaccharides
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Recombinant Proteins
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Tumor Necrosis Factor-alpha