Successful treatment with narrow-band UVB therapy for a case of generalized Hailey-Hailey disease with a novel splice-site mutation in ATP2C1 gene

Kana Mizuno; Takahiro Hamada; Takashi Hashimoto; Hiroyuki Okamoto

doi:10.1111/dth.12125

Successful treatment with narrow-band UVB therapy for a case of generalized Hailey-Hailey disease with a novel splice-site mutation in ATP2C1 gene

Dermatol Ther. 2014 Jul-Aug;27(4):233-5. doi: 10.1111/dth.12125. Epub 2014 Jun 24.

Authors

Kana Mizuno¹, Takahiro Hamada, Takashi Hashimoto, Hiroyuki Okamoto

Affiliation

¹ Department of Dermatology, Kansai Medical University, Hirakata, Japan.

PMID: 24962025
DOI: 10.1111/dth.12125

Abstract

Hailey-Hailey disease (HHD) is a rare autosomal dominant disorder characterized by development of recurrent blisters, erosions, and crustations in the intertriginous areas. The treatment of HHD is often challenging, and various methods have been tried. We report here a case of a 45-year-old woman with a generalized form of HHD that was dramatically improved and well controlled by narrow-band ultraviolet B phototherapy.

Keywords: Hailey-Hailey disease; narrow-band UVB phototherapy.

Publication types

Case Reports

MeSH terms

Calcium-Transporting ATPases / genetics*
Female
Humans
Middle Aged
Mutation / genetics
Pemphigus, Benign Familial / genetics
Pemphigus, Benign Familial / radiotherapy*
RNA Splice Sites / genetics
Treatment Outcome
Ultraviolet Therapy / methods*

Substances

RNA Splice Sites
ATP2C1 protein, human
Calcium-Transporting ATPases